Abstract
Introduction: Advances in the operational mode of the cerebellum indicate a role in sequencing and predicting non-social and social events, crucial for individuals to optimize high-order functions, such as Theory of Mind (ToM). ToM deficits have been described in patients with remitted bipolar disorders (BD). The literature on BD patients’ pathophysiology reports cerebellar alterations; however, sequential abilities have never been investigated and no study has previously focused on prediction abilities, which are needed to properly interpret events and to adapt to changes.
Methods: To address this gap, we compared the performance of BD patients in the euthymic phase with healthy controls using two tests that require predictive processing: a ToM test that require implicit sequential processing and a test that explicitly assesses sequential abilities in non-ToM functions. Additionally, patterns of cerebellar gray matter (GM) alterations were compared between BD patients and controls using voxel-based morphometry.
Results: Impaired ToM and sequential skills were detected in BD patients, specifically when tasks required a greater predictive load. Behavioral performances might be consistent with patterns of GM reduction in cerebellar lobules Crus I-II, which are involved in advanced human functions.
Discussion: These results highlight the importance of deepening the cerebellar role in sequential and prediction abilities in patients with BD.
Links
- https://apc.it/2023-gragnani-the-role-of-the-cerebellum/
- doi:https://doi.org/10.3389/fncel.2023.1095157
BibTeX (Download)
@article{Siciliano2023,
title = {The role of the cerebellum in sequencing and predicting social and non-social events in patients with bipolar disorder},
author = {Libera Siciliano and Giusy Olivito and Michela Lupo and Nicole Urbini and Andrea Gragnani and Marco Saettoni and Roberto Delle Chiaie and Maria Leggio},
editor = {Frontiers},
url = {https://apc.it/2023-gragnani-the-role-of-the-cerebellum/},
doi = {https://doi.org/10.3389/fncel.2023.1095157},
year = {2023},
date = {2023-02-15},
urldate = {2023-02-15},
journal = {Frontiers in Cellular Neuroscience},
abstract = {Introduction: Advances in the operational mode of the cerebellum indicate a role in sequencing and predicting non-social and social events, crucial for individuals to optimize high-order functions, such as Theory of Mind (ToM). ToM deficits have been described in patients with remitted bipolar disorders (BD). The literature on BD patients’ pathophysiology reports cerebellar alterations; however, sequential abilities have never been investigated and no study has previously focused on prediction abilities, which are needed to properly interpret events and to adapt to changes.
Methods: To address this gap, we compared the performance of BD patients in the euthymic phase with healthy controls using two tests that require predictive processing: a ToM test that require implicit sequential processing and a test that explicitly assesses sequential abilities in non-ToM functions. Additionally, patterns of cerebellar gray matter (GM) alterations were compared between BD patients and controls using voxel-based morphometry.
Results: Impaired ToM and sequential skills were detected in BD patients, specifically when tasks required a greater predictive load. Behavioral performances might be consistent with patterns of GM reduction in cerebellar lobules Crus I-II, which are involved in advanced human functions.
Discussion: These results highlight the importance of deepening the cerebellar role in sequential and prediction abilities in patients with BD.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
